Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women

  • STATUS
    Recruiting
  • End date
    Jan 30, 2023
  • participants needed
    100
  • sponsor
    Genesis Athens Clinic
Updated on 25 January 2021
acupuncture
hormone replacement therapy

Summary

Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve hormonal profile of women in menopause.

Description

This triple-blind Randomized Controlled Trial (RCT) aims to investigate the effectiveness of autologous PRP intra ovarian infusion on reactivating ovarian functionality and on promoting folliculogenesis in regard to menopausal women. PRP is blood plasma prepared from fresh whole blood that has been enriched with platelets. It is collected from peripheral veins and contains several growth factors such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factor (TGF) and other cytokines all of which stimulate tissue proliferation and growth. PRP has been employed in several medical conditions in Orthopedics, Dermatology, and Ophthalmology for wound healing. It's efficacy in ovarian rejuvenation and reactivation and endometrial regeneration has not been fully elucidated. This study aims to investigate the effect of autologous PRP intra ovarian infusion on restoring ovarian tissue functionality in menopausal women.

Details
Condition Amenorrhea, Female infertility, Menopause, Hypomenorrhea, Menstrual Disorders, Anovulatory Infertility
Treatment Placebo, PRP, Autologous PRP intra ovarian infusion, Autologous PFP intra ovarian infusion
Clinical Study IdentifierNCT03916978
SponsorGenesis Athens Clinic
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age between 45-55 years old
Amenorrhea for at least 12 months
Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment
Willing to comply with study requirements

Exclusion Criteria

Any pathological disorder related to reproductive system anatomy
Previous POI diagnosis
Abnormal karyotype
Endometriosis
Adenomyosis
Fibroids and adhesions
Infections in reproductive system
Current or previous diagnosis of reproductive system cancer
History of familiar cancer in reproductive system
Severe male factor infertility
Prior referral for PGT
Ovarian inaccessibility
Endocrinological disorders (Hypothalamus-Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
BMI>30 kg/m2 or BMI<18.5 kg/m2
Systematic autoimmune disorders
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