Pharmacokinetic Study of Vancomycin, Clindamycin and/or Gentamicin Administration During Surgery Using a Microdialysis Procedure

  • participants needed
  • sponsor
    Poitiers University Hospital
Updated on 3 December 2022
antibiotic therapy
antibiotic prophylaxis
site infection


The surgical site infection is one of the most important causes of postoperative morbidity. The appropriate antibiotic prophylaxis is one of the most effective way to prevent surgical site infections. The beta-lactam are the most frequent antibiotics recommended for surgical prophylaxis and patients known to be allergic to beta-lactam are more likely to presented surgical site infection, probably due to use of others antibiotic such as vancomycin or clindamycin.

The main objective of the study is to describe the tissu and plasma pharmacokinetics of vancomycin, clindamycin and gentamicin using as surgical antibiotic prophylaxis in patients with beta-lactam hypersensivity and to predict the probability of target attainment for usual bacteria.

Condition Surgical Site Infection
Treatment Blood and microdialysis samples
Clinical Study IdentifierNCT03845790
SponsorPoitiers University Hospital
Last Modified on3 December 2022

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