Pharmacokinetic Study of Vancomycin, Clindamycin and/or Gentamicin Administration During Surgery Using a Microdialysis Procedure

  • STATUS
    Recruiting
  • days left to enroll
    64
  • participants needed
    16
  • sponsor
    Poitiers University Hospital
Updated on 9 February 2022
antibiotic therapy
antibiotics
vancomycin
clindamycin
gentamicin
antibiotic prophylaxis
site infection

Summary

The surgical site infection is one of the most important causes of postoperative morbidity. The appropriate antibiotic prophylaxis is one of the most effective way to prevent surgical site infections. The beta-lactam are the most frequent antibiotics recommended for surgical prophylaxis and patients known to be allergic to beta-lactam are more likely to presented surgical site infection, probably due to use of others antibiotic such as vancomycin or clindamycin.

The main objective of the study is to describe the tissu and plasma pharmacokinetics of vancomycin, clindamycin and gentamicin using as surgical antibiotic prophylaxis in patients with beta-lactam hypersensivity and to predict the probability of target attainment for usual bacteria.

Details
Condition Surgical Site Infection
Treatment Blood and microdialysis samples
Clinical Study IdentifierNCT03845790
SponsorPoitiers University Hospital
Last Modified on9 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult patient between 18 and 80 years old
Patient with history of beta-lactam hypersensitivity
Patient who underwent abdominal or orthopedic surgery whose forseeable time exceeds 1 hour and requires a surgical antibiotic prophylaxis by vancomycin or clindamycin + gentamicin

Exclusion Criteria

morbid obesity (BMI > 35 kg/m2)
mild to severe renal impairment (clearance creatinine < 60 ml/min)
vancomycin, clindamycin or gentamicin hypersensitivity
pregnancy
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