Electroacupuncture for Patients With Chronic Urinary Retention Secondary to Lower Motor Neuron Lesion

  • End date
    Dec 28, 2022
  • participants needed
  • sponsor
    Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Updated on 28 November 2021


Chronic Urinary Retention (CUR) is defined as a non-painful bladder which remains palpable or percussible after the patient has passed urine by International Continence Society. Postvoid residual urine volume 300 mL seems to be widely accepted.

CUR may be caused by a variety of diseases and events including injury of sacral plexus, cauda equina and sacral spinal cord, pelvic floor nerve lesion after pelvic surgery and peripheral neuropathy due to diabetes, etc.. Aforementioned injuries generally affect lower motor neuron causing detrusor underactivity, acontractile detrusor or detrusor areflexia. The prevalence varies by different causes of lower motor neuron lesion. The symptoms of patients are voiding difficulty, bladder distention, bladder without sensation and overflow incontinence.

A multi-center randomized sham-controlled trial will be conducted. The aim of this study is to assess the efficacy and safety of electroacupuncture for urinary function of patients with CUR caused by lower motor neuron lesion.

Condition Chronic Urinary Retention
Treatment Electroacupuncture, Sham electroacupuncture
Clinical Study IdentifierNCT03662906
SponsorGuang'anmen Hospital of China Academy of Chinese Medical Sciences
Last Modified on28 November 2021


Yes No Not Sure

Inclusion Criteria

Have chronic urinary retention caused by lower motor neuron damage
Age 18 to 75 years
Have chronic urinary retention caused by injury of sacral plexus, cauda equina and sacral spinal cord, pelvic floor nerve lesion after pelvic surgery and peripheral neuropathy due to diabetes
Have postvoid residual urine volume 300 mL or more and sensation of bladder
Bladder contractile index is more than 100 or more
Duration of disease is more than 3 months
Intermittent clean catheterization or indwelling catheterization
Sign informed consent and participate in the study voluntarily

Exclusion Criteria

Have urinary retention due to bladder outlet obstruction (bladder neck contracture, urethral stricture, prostate cancer, prostatic hyperplasia, etc.)
Have urinary system tumors or stones
Have detrusor underactivity due to other non-lower motor neurogenic disease
Have bowel and urinary disorder due to lesions or injuries of thoracic spinal cord, cervical spinal cord and brain
After suprapubic cystostomy
Have heart, liver, kidney, mental disorders or coagulation disorders
Have been implanted a cardiac pacemaker, sacral nerve stimulation electrode, pudendal nerve stimulation electrode, or bladder stimulation electrode
During pregnancy or in lactation
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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