Nitrite-boosting Therapy for Improving Physiological Function in Patients With Chronic Kidney Disease

  • STATUS
    Recruiting
  • End date
    Jul 23, 2023
  • participants needed
    92
  • sponsor
    University of Colorado, Boulder
Updated on 23 January 2021
nephropathy
renal function study

Summary

Nitric oxide (NO) is an essential molecule in the body that is decreased in patients with chronic kidney disease (CKD), leading to reductions in vascular, movement ("motor") and cognitive functions. This study will determine if daily oral supplementation (3 months) with a supplement that increases NO in the body, i.e., nitrate-rich beetroot juice, improves vascular, motor and cognitive function in patients with CKD; this study will also provide insight into the biological reasons (mechanisms) by which supplementation with nitrate-rich beetroot juice improves vascular function in these patients. Overall, this research will provide scientific evidence supporting the use of nitrate-rich beetroot juice for preserving physiological function and preventing co-morbid clinical conditions and disability in CKD.

Details
Condition chronic renal insufficiency, Chronic renal failure, chronic kidney disease, chronic kidney disease (ckd)
Treatment Nitrate-rich Beetroot Juice, Nitrate-depleted beetroot juice
Clinical Study IdentifierNCT03826147
SponsorUniversity of Colorado, Boulder
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 30 yrs and 80 yrs?
Gender: Male or Female
Do you have any of these conditions: Chronic renal failure or chronic renal insufficiency?
Do you have any of these conditions: chronic kidney disease or Chronic renal failure or chronic renal insufficiency or chronic kidney disease (ckd)?
CKD stage II-IV (eGFR using the Modification of Diet in Renal Disease (MDRD) prediction equation 20-90 mL/min/1.73m2; stable renal function in the past 3 months)
Ability to give informed consent
Albumin > 3.0 g/dL
Ability to perform motor and cognitive tests (e.g., can rise from a chair, walk for 6 min, climb 10 stairs)
Free from alcohol dependence or abuse, as defined by the American Psychiatry Association, Diagnostic and Statistical Manual of Mental Disorders (DSM-V)
Mini-mental state examination score >21 (rationale: to screen for subjects with major cognitive impairment)
Blood pressure (BP) >100/60 mmHg for past 3 months (rationale: blood pressure below 100/60 mmHg may elevate the normally small risk of hypotension with nitrate supplementation)
Not taking medications that will interfere with administered medications (e.g., sildenafil interacts with nitroglycerin)
Body mass index (BMI) <40 kg/m2 (vascular function measurements can be inaccurate in severely obese patients)

Exclusion Criteria

Life expectancy <1 year
Uncontrolled hypertension, defined as blood pressure > 160/100 mmHg in the past 3 months
History of severe liver disease
History of severe congestive heart failure (i.e., ejection fraction < 35%)
History of hospitalizations within the last 3 months
Active infection or antibiotic therapy
Warfarin use
Vasculitis requiring immunosuppressive therapy within the last year
High dietary nitrate intake or current nitrate/nitrite supplementation; hypersensitivity to nitrates or nitrites
Glucose-6-phosphate dehydrogenase deficiency or blood methemoglobin >2%
Unwilling to abstain from use of mouthwash or other oral hygiene practices (e.g., tongue scraping) outside of teeth brushing that disrupt the oral microbiome and would interfere with nitrate conversion to nitrite
Blood donation within 8 weeks prior to enrolling in the study; unwilling to abstain from donating blood for 8 weeks after completing the study
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