Social Determinants of Health in Glioblastoma Population

  • STATUS
    Recruiting
  • days left to enroll
    30
  • participants needed
    115
  • sponsor
    Wake Forest University Health Sciences
Updated on 4 October 2022
cancer
ependymoma
glioblastoma multiforme
astrocytoma
oligodendroglioma
ganglioglioma

Summary

The overall aim of this study is to prospectively characterize social health disparities in a cross-sectional cohort of glioma patients with attention to exploring and thematically categorizing the patient-specific and community-level factors. This will be conducted in two parts.

Description

Part 1:

Primary Objectives

  1. To describe the social determinants of health in a cross-section of patients with WHO Grade 2-4 gliomas using a group of validated instruments including the PRAPARE instrument, the Accountable Health Communities Health-Related Social Needs Screening Tool (AHC HRSN), and supplementary questions.

Secondary Objectives

  1. To compare social determinants of health between patients residing in economically disadvantaged and advantaged communities as defined in our prior study (low income communities vs high income county communities, by zip code).
  2. To compare social determinants of health between patients residing in economically disadvantaged and advantaged communities as defined by other means including county (low income communities vs high income communities, by county), by urban vs rural (urban vs rural, by city), and by area deprivation index (see Section 5.2).
  3. To quantify and compare the patient- and community-level social determinants of health present in the cohort and by community (low income community vs high income community).
  4. To compare the time to presentation, time to treatment initiation, and extent of surgery for patients from economically disadvantaged and advantaged communities as described above.

Part 2:

Data from our preliminary study revealed differences in survival for patients from low income communities compared to high income community zip codes. The overarching goal of Part 2 is to further characterize the social factors that characterize low income community and high income communities and may contribute to the differences in outcome.

Primary Aim

  1. To identify, compare, contrast, and contextualize the patient- and community-specific social determinants for patients residing in (1) low income communities and high income community zip codes and (2) urban and rural communities.
  2. To explore how patients perceive communication with their providers about social and community factors that contribute to health outcomes and understand the barriers, challenges, and opportunities to improve patient-provider communication.

Details
Condition Glioma, Astrocytoma, Oligodendroglioma, Ependymoma, Ganglioglioma, Pleomorphic Xanthoastrocytoma
Treatment Part 1 Survey Group, Part 2 Focus Group
Clinical Study IdentifierNCT03900689
SponsorWake Forest University Health Sciences
Last Modified on4 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Part 1
Adults who are 18 years or older
Have a histologically confirmed glioma of any grade (WHO Grade 2-4: astrocytoma, oligodendroglioma, ependymoma, ganglioglioma, pleomorphic xanthroastrocytoma)
Currently receiving primary oncologic care at Wake Forest Baptist Comprehensive Cancer Center
Have the ability to speak and read either English or Spanish
Ability to provide informed consent
Part 2
Participants who participated in Part 1 and express willingness to be contacted about Part 2
Ability to provide informed consent
Ability to speak and understand English
Inclusion of Women and Minorities (for Part 1 and Part 2)
• Women of all races and ethnicity who meet the above-described eligibility criteria are
eligible for this trial

Exclusion Criteria

• Patients who are unable to read or complete the required study-related forms. Patients
who are unable to read but can be assisted by a proxy or family member will be included
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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