Imaging Markers of Subclinical Cardiotoxicity in Breast Cancer

  • End date
    Jul 17, 2022
  • participants needed
  • sponsor
    Dana-Farber Cancer Institute
Updated on 17 February 2021
breast carcinoma


This research study is evaluating the use of Cardiac Magnetic Resonance Imaging (CMR) as a method of detecting early signs of damage to the heart that can be associated with anthracycline-based chemotherapy for the treatment of breast cancer.


One of the side effects observed in breast cancer patients receiving anthracycline-based treatment is heart complications in which the heart muscle is weakened and no longer able to pump sufficient amounts of blood throughout the body. This complication can lead to the following symptoms: shortness of breath on exertion, swollen ankles and feet, lack of energy and a reduced capacity to carry out day-to-day activities.

This research study is focused on identifying the early signs of such heart complications using CMR, which may allow preventative treatment options to be made available in future.

Condition Breast Cancer, Breast Cancer Diagnosis, breast carcinoma, cancer, breast
Treatment Cardiac magnetic resonance imaging (CMR), Echocardiogram (ECHO)
Clinical Study IdentifierNCT02666378
SponsorDana-Farber Cancer Institute
Last Modified on17 February 2021


Yes No Not Sure

Inclusion Criteria

Age > 18 years
Have histologic diagnosis of breast carcinoma
Scheduled to receive standard clinical therapy designed by their treating oncologist
Patients should receive anthracycline as part of the recommended treatment
Able to give informed consent

Exclusion Criteria

Contraindication to contrast CMR including eGFR <30 mls/min/1.73m2
Uncontrolled serious concurrent illness
Pregnancy or breast feeding
Clear my responses

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