Combination of Anti-PD-1 Antibody and Chemotherapy in Metastatic Pancreatic Cancer

  • participants needed
  • sponsor
    Zhejiang University
Updated on 30 June 2022
cancer chemotherapy
metastatic pancreatic cancer
pancreatic ductal adenocarcinoma
breast ductal carcinoma


The prognosis of pancreatic cancer is extremely poor. NCCN guidelines recommend FOLFIRINOX or modified-FOLFIRINOX as the first-line chemotherapeutic regimen. Studies have shown that immunotherapy with Anti-PD-1 antibody can effectively increase the response rate and prolong patient survival in a number of cancer diseases. Here investigators intend to compare the therapeutic effects of modified-FOLFIRINOX alone and the combination of modified-FOLFIRINOX and Anti-PD-1 antibody in patients with metastatic pancreatic cancer.


Metastatic pancreatic cancer patients will be enrolled in this trial. Investigators will assign patients to the treatment after randomization. The primary endpoint is overall survival. Response rate, progression-free survival, drugs related side effects and other endpoints events will be recorded and analyzed, to assess the combination treatment with modified-FOLFIRINOX and Anti-PD-1 antibody could or couldn't benefit the patients with metastatic pancreatic cancer.

Condition Pancreatic Cancer
Treatment Chemotherapy, Combination drug, Combination drug
Clinical Study IdentifierNCT03977272
SponsorZhejiang University
Last Modified on30 June 2022

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