Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
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- STATUS
- Recruiting
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- End date
- Mar 15, 2025
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- participants needed
- 184
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- sponsor
- Pfizer
Summary
A study to learn about safety and find out maximum tolerable dose of palbociclib given in combination with chemotherapy (temozolomide with irinotecan or topotecan with cyclophosphamide) in children, adolescents and young adults with recurrent or refractory solid tumors (phase 1). Phase 2 to learn about the efficacy of palbociclib in combination with irinotecan and temozolomide when compared with irinotecan and temozolomide alone in the treatment of children, adolescents, and young adults with recurrent or refractory Ewing sarcoma (EWS).
Details
| Condition | Ewing Sarcoma, Solid Tumors, Rhabdoid Tumor, Rhabdomyosarcoma, Neuroblastoma, Medulloblastoma, Diffuse Intrinsic Pontine Glioma |
|---|---|
| Treatment | cyclophosphamide, Topotecan, Temozolomide, Irinotecan, Palbociclib |
| Clinical Study Identifier | NCT03709680 |
| Sponsor | Pfizer |
| Last Modified on | 12 April 2023 |
Eligibility
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