The purpose of this study is to determine whether IFX-1 is safe and effective in the treatment of pyoderma gangrenosum.
Neutrophilic dermatoses are a spectrum of inflammatory disorders characterized by skin lesions resulting from a neutrophil-rich inflammatory infiltrate in the absence of infection. Pyoderma gangrenosum is associated with a neutrophilic leukocytosis, which is likely to be triggered by C5a. This study is set up based on the hypothesis that IFX-1 might be able to block C5a induced pro-inflammatory effects such as neutrophil activation and cytokine generation, potentially contributing to the local skin inflammation and tissue damage.
| Condition | Pyoderma Gangrenosum |
|---|---|
| Treatment | IFX-1 |
| Clinical Study Identifier | NCT03971643 |
| Sponsor | InflaRx GmbH |
| Last Modified on | 29 May 2022 |
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