Effects of Lingzhi on Disease Progression in Patients With Untreated Early Parkinson's Disease

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  • participants needed
  • sponsor
    Xuanwu Hospital, Beijing
Updated on 5 September 2021
antiparkinsonian agents
early parkinson's


Lingzhi(Ganoderma) is widely used in traditional Chinese medicine. Previous studies indicated that Lingzhi was safe, well tolorated, and improved symptoms as an add-on therapy to levodopa in early Parkinson's disease(PD) patients. Here the investigators design a multicenter, randomized, double-blind, placebo-controlled, delayed-start trial to evaluate the effects of Lingzhi on modifying disease progression in untreated PD patients.

Condition Parkinson's disease, parkinson's, parkinson disease
Treatment placebos, Ganoderma, Ganoderma
Clinical Study IdentifierNCT03594656
SponsorXuanwu Hospital, Beijing
Last Modified on5 September 2021


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Inclusion Criteria

Meeting the criteria for "Probable Parkinson's disease" according to 2015 MDS Clinical Diagnostic Criteria for Parkinson's Disease
Aged 30-80 years
Hoehn-Yahr Stage2
UPDRS Part III subscores ranging from 10 to 30 points
Disease duration of 5 years or less
Untreated with antiparkinsonian drugs for at least two weeks preceding the trial
Willing to sign the written informed consent

Exclusion Criteria

Atypical or secondary parkinsonism
With psychiatric symptoms or a history of psychiatric diseases
With cognitive impairment(MMSE score<24)
Major liver or kidney dysfunction
Participating in other clinical trials within 3 months preceding the current trial
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