Last updated on June 2019

Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth


Brief description of study

The current study investigates the feasibility and safety of allogeneic mesenchymal stem/stromal cells in previous oropharynx cancer patients with radiation-induced hyposalivation and xerostomia

Detailed Study Description

Hyposalivation and xerostomia are the most common long-term side effects to radiotherapy of head and neck cancers.

A randomized clinical trial indicates that autologeous mesenchymal stem/stromal cells can restore function of the submandibular glands.

Patients with previous oropharynx cancer and radiation-induced hyposalivation and xerostomia will be treated with culture expanded adipose tissue derived mesenchymal stem/stromal cells from healthy donors.

The patients will be followed for 4 months for safety and efficacy registration

Clinical Study Identifier: NCT03874572

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Recruitment Status: Open


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