Adaptive Radiotherapy for High-risk Prostate Cancer Using Multiparametric MRI

  • STATUS
    Recruiting
  • End date
    Sep 30, 2022
  • participants needed
    15
  • sponsor
    East and North Hertfordshire NHS Trust
Updated on 27 January 2021
androgens
antiandrogen therapy
androgen suppression
multiparametric magnetic resonance imaging
external beam radiotherapy

Summary

This small study will investigate the feasibility of using multi-parametric MRI to introduce and support adaptive radiotherapy treatments for high-risk prostate cancer.

Description

Mount Vernon Cancer Centre at East and North Hertfordshire NHS Trust offers patients with certain cancers a treatment called adaptive radiotherapy. The aim of adaptive radiotherapy is to respond to physical changes that occur during treatment to ensure the radiation continues to be directed at the cancer and to minimise the amount of healthy tissue treated. For example, if tumour shrinkage or weight loss occurs during head and neck radiotherapy the patient may have a repeat CT scan and a new radiotherapy treatment plan after a few weeks of treatment. For patients with cancer of the bladder or cervix changes in bladder and uterus size and position can be predicted allowing the prospective creation of three radiotherapy treatment plans, each day the best fitting plan, i.e. the one that closely covers the tumour whilst giving minimal dose to normal tissues, is selected and used for treatment, this is known as plan-of-the-day adaptive radiotherapy.

Small changes in shape and position of the prostate occur but are generally the result of rectal changes which cannot be predicted, consequently adaptive radiotherapy based on physical change is not possible for prostate cancer treatments. However, recent literature suggests that magnetic resonance imaging (MRI) can detect changes within the prostate in response to radiotherapy, some studies have seen changes as early as the second week of radiotherapy treatment. A feasibility study to investigate if these changes can support radiotherapy treatment plan adaption for prostate cancer treatments is proposed, whether the plan can be adapted to give a higher treatment dose to any areas of the prostate that show poor response to radiotherapy without increasing bowel and bladder dose is of particular interest. The treatment for patients who participate in the study would not be changed but the results may help to personalise and improve the treatment of future patients.

Details
Condition Malignant neoplasm of prostate, Prostatic disorder, Prostate Disorders, Prostate Cancer, Early, Recurrent, Prostate Cancer, prostate carcinoma, prostate cancers
Clinical Study IdentifierNCT03967080
SponsorEast and North Hertfordshire NHS Trust
Last Modified on27 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

New diagnosis of high-risk prostate cancer: any of
Gleason score of 8, 9 or 10
PSA > 20
T3/4
Patient due to receive androgen deprivation therapy (ADT)
Prescribed 78Gy/39# external beam radiotherapy
Measurable dominant intraprostatic tumour on diagnostic imaging of at least 10mm diameter
18 years of age
ECOG performance status of 0-1
Informed, written and witnessed consent to participate is required

Exclusion Criteria

Patients who are not due to receive androgen deprivation therapy (ADT)
Any contraindication to MRI scanning including contraindication to MRI contrast agents
Previous radiotherapy to the pelvis
Any physical or social reasons that would make attendance for additional visits impossible
Any patient with or planned for prostate fiducial markers
Unable to give informed consent
Patients currently enrolled in an interventional clinical trial
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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