Physical Exercise for Prevention of Dementia

  • days left to enroll
  • participants needed
  • sponsor
    University of Molise
Updated on 23 January 2021
cognitive decline
mental deterioration


The principal aim of this study is to verify whether a program of supervised, multimodal physical exercise improves cognitive function and/or reduces the rate of cognitive decline in older adults


Community-dwelling volunteers, recruited from social centers, were invited to an in-person assessment that included a medical history questionnaire and examination, anthropometric measurements, blood tests for cardiovascular risk, and several outcome measures. Participants meeting the inclusion criteria were divided in 3 groups (participants without subjective or objective cognitive impairment, with subjective memory complaints and with mild cognitive impairments) and randomly assigned (1:1) to an experimental group or a control group, using a list of random numbers generated by a statistical software. The list was kept in a sealed envelope and a researcher, not directly involved in the recruitment and in the evaluation of the participants, assigned the allocation numbers.

Condition Senility, Memory impairment, Mild Cognitive Impairment, Mild Neurocognitive Disorder, Aging, memory disorders, memory disorder
Treatment Control group, Intervention group
Clinical Study IdentifierNCT02236416
SponsorUniversity of Molise
Last Modified on23 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age between 50 yrs and 90 yrs?
Gender: Male or Female
Do you have any of these conditions: Memory impairment or Aging or Senility or Mild Cognitive Impairment?
Do you have any of these conditions: Senility or Aging or Mild Cognitive Impairment or Memory impairment or Mild Neurocognitive Disorder or memory disorders or memory disorder?
Age > 50 years old

Exclusion Criteria

Medical conditions that compromise survival or limit physical activity
Geriatric Depression Scale-15 score of 6 or higher
Alcohol intake > 4 units/day
Mini- Mental State Examination < 24
Clinical Dementia Rating score of 1 or more
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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