Citrate Anticoagulation for Postdilution Hemofiltration

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  • sponsor
    Heinrich-Heine University, Duesseldorf
Updated on 24 January 2021
critical illness
renal injury
renal replacement
replacement therapy
renal replacement therapy


This study evaluates a protocol for regional citrate anticoagulation in critically ill patients with acute kidney injury who are treated with continuous veno-venous haemofiltration in postdilution mode.


Acute kidney injury (AKI) requiring continuous renal replacement therapy (CCRT occurs in approx. 15 % of all intensive care patients. A sustained and prolonged filter running time is required to deliver an effective dialysis dose. This requires effective anticoagulation. Today, regional citrate anticoagulation (RCA) is preferred over systemic anticoagulation because of prolonged filter lifetimes and less adverse effects.

We here study prospectively patients with AKI who are treated with continuous veno-venous haemofiltration using an RCA protocol.

We will evaluate all parameters of CRRT including filter running times, delivered dialysis dose, causes for treatment interruption and control of pH and electrolytes.

Condition Renal Failure, Acute renal failure, Critical Illness, Kidney Failure (Pediatric), Kidney Failure, critically ill, acute kidney injury, acute kidney injuries
Treatment renal replacement therapy as clinically indicated
Clinical Study IdentifierNCT03969966
SponsorHeinrich-Heine University, Duesseldorf
Last Modified on24 January 2021


Yes No Not Sure

Inclusion Criteria

acute kidney injury
critical illness and treatment at ICU

Exclusion Criteria

age < 18 years
pregnancy or breast feeding
severe lactate acidosis ( > 10 mmol/l) for longer than 6 hours and pH < 7.2
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