Light-CT in the Diagnosis of Breast Tumor and Lymph Node

  • STATUS
    Recruiting
  • End date
    Dec 31, 2023
  • participants needed
    150
  • sponsor
    Peking University People's Hospital
Updated on 9 February 2022
cancer
breast surgery
breast cancer
cancer diagnosis

Summary

Intraoperative pathological diagnosis such as frozen section and imprint cytology is not routinely recommended in clinical practice because of time and accuracy concerns. Full-field optical coherence tomography (FF-OCT) is a new optical imaging technique that could generate sectioning tomogram from fresh tissue and provide close-to-pathology depiction of the morphological structure and pathological changes in minutes without conventional tissue preparation, slicing, and staining, and dynamic cell imaging (DCI) added the viability information of cells/tissue, which could be more important in cancer diagnosis. This study was to evaluate the feasibility and diagnostic value of FF-OCT and DCI in breast lesions and lymph node specimens during breast cancer surgery. We evaluated normal breast tissue, benign breast lesions, breast cancer and axillary lymph node specimens resected from patients undergoing breast surgery.

Description

Light-CT, a special-designed pathology-approximation system which is based on the lighting feature or dynamic feature of tissue and cells, is used to detect malignant cells or tissue in fresh specimens. Morphological structure and pathological changes could be captured in minutes, which implies a possible application in intraoperative diagnosis. In this study, fresh breast tissue, fat, benign breast lesions, breast cancer and axillary lymph node specimens are collected to assess the usefulness of Light-CT. During the in vitro examination, both FF-OCT and DCI images are obtained and stored. Imaging analysis would be performed in traditional imaging analysis like manner and an artificial intelligence aided approach as well.

In this study, breast and lymph node specimens would be collected and imaged both through light imaging and conventional pathological analysis.

Details
Condition Breast Neoplasms
Treatment Light-CT
Clinical Study IdentifierNCT03791853
SponsorPeking University People's Hospital
Last Modified on9 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients planning to undergoing breast surgery/surgical lymph node staging
Specimen could be obtained

Exclusion Criteria

Prior open biopsy
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