Tick-borne Encephalitis and Borrelial Antibodies in Serum

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    University Medical Centre Ljubljana
Updated on 26 May 2022
Accepts healthy volunteers


In Slovenia, tick-borne encephalitis and Lyme borreliosis are both endemic diseases with high incidence rates and they are both transmitted by a bite of infected Ixodes ricinus tick. In clinical practice, tick-borne encephalitis is confirmed by demonstration of tick-borne encephalitis antibodies in serum of a patient with compatible clinical presentation and cerebrospinal pleocytosis. Patients with Lyme meningitis or meningoradiculitis also have cerebrospinal pleocytosis, however the presence of borrelial antibodies in serum does not attest Lyme neuroborreliosis. Patients with tick-borne encephalitis and positive borrelial antibodies in serum, but not fulfilling criteria for Lyme neuroborreliosis, are often being treated with antibiotics in several European countries due to the possibility of double infection. The investigators hypothesise that such patients do not benefit from antibiotics. Such an approach may appear safe regarding the possibility of borrelial infection, however it can also be associated with detrimental consequences such as antibiotic related adverse reactions, negative epidemiological impact on bacterial resistance, and intravenous catheter related complications.

Condition Tick Borne Encephalitis
Treatment doxycycline, Questionnaire, Symptomatic therapy
Clinical Study IdentifierNCT03956446
SponsorUniversity Medical Centre Ljubljana
Last Modified on26 May 2022


Yes No Not Sure

Inclusion Criteria

years or older
clinical picture compatible with tick-borne encephalitis
clear cerebrospinal fluid
cerebrospinal pleocytosis (leucocytes in cerebrospinal fluid >5 x 106/)L
positive serum immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against tick-borne encephalitis virus
positive serum IgG antibodies against Lyme borreliae

Exclusion Criteria

isolation of B.burgdorferi sensu lato from cerebrospinal fluid
positive intrathecal borrelial antibody production index
seroconversion of borrelial IgG antibodies
presence of erythema migrans and/or borrelial lymphocytoma in the last month
Bannwarth syndrome
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