Clinical Trial of Minimally Invasive Surgery Versus Abdominal Surgery in Patients With Early Stage Cervical Cancer (RWS-01)

  • STATUS
    Recruiting
  • End date
    May 23, 2024
  • participants needed
    2000
  • sponsor
    Ding Ma
Updated on 8 February 2022
cancer
hysterectomy
carcinoma
squamous cell carcinoma
adenosquamous carcinoma
adenocarcinoma
cervical carcinoma
cervical disease
cervical cancer stage
cervical lesion

Summary

Cervical cancer is the most common cause of death from gynecological cancer world-wide. With technological innovation, minimally invasive or even non-invasive medical treatment has become a trend. Since the first cases of laparoscopic radical hysterectomy of cervical cancer have been reported in 1992, many single-center observational cohort studies have shown that compared to open abdominal surgery minimally invasive surgery (laparoscopic or robotic radical hysterectomy) showed advantages of less blood loss, shorter hospital stay and fewer intraoperative complications, while the 5-year survival and disease-free survival were similar. The NCCN guidelines and ESGO recommendations also clearly indicated that patients with FIGO stage IA2 -IIA cervical cancer could undergo open or laparoscopic/robotic radical hysterectomy. However, in October 2018, the results of two studies published in theNew England Journal of Medicinehave subverted our traditional perception of minimally invasive surgery and caused widespread controversy in the field of gynecologic oncology treatment. Both studies showed that the survival rate in the minimally invasive surgery group was lower than that in the open surgery group.

The results of these two studies have brought unprecedented doubts and challenges to the minimally invasive surgery for cervical cancer. The MD Anderson Cancer Center has even stopped minimally invasive surgery for cervical cancer. Several hospitals in Hong Kong have responded similarly. The NCCN guidelines are also quickly updated based on the results of those studies: patients should be informed of the results of this study and doctors should respect the patient's choices. The above research results have also attracted the attention of many gynecological oncologists in the mainland China. Some experts questioned the design of this study design as well as surgical skills. We need to look at these findings cautiously. So, we launched a real-world study of clinical outcomes affected by different surgical treatment for patients of early stage cervical cancer. We plan to recruit 2000 patients with early cervical cancer from 20-30 selected surgical centers nationwide and perform surgery on patients with qualified and experienced doctors.We will inform the patients current status of the study in detail, divide the patients into different observational group according to their choices on surgical methods. The patients will be followed up closely after surgery. We will compare the differences in clinical outcomes between the two surgical methods and conduct subgroup and stratified analysis. We hope that this study can truly reflect the actual status and clinical l level of early cervical cancer treatment in China, and provide a high level of clinical evidence for the treatment of cervical cancer in China .

Description

The study is a non-randomized, prospective, multi-center, clinical study.Patients with early cervical cancer who were enrolled will be divided into two groups: minimally invasive surgery group (group A) and open abdominal surgery group (group B) according to the patient's choice on surgical methods.We will standardize the surgery details according to the factors that may affect the prognosis of cancer treatment in the minimally invasive surgery of cervical cancer, such as : emphasizing the tumor-free principle of surgery; using a ligation band to tighten the vagina before cutting the vagina; avoiding the use of the cup-shaped uterine manipulatorreducing frequent changes in CO2 abdominal pressureor using a laparoscope-assist transvaginal hysterectomy and other methods to avoid the risk of tumor tissue shedding. Patients with high risk factors after surgery will receive follow-up treatment according to the 2018 NCCN guidelines.

Details
Condition Uterine Cervical Neoplasm
Treatment minimally invasive surgery, minimally invasive surgery, open abdominal surgery
Clinical Study IdentifierNCT03955185
SponsorDing Ma
Last Modified on8 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with FIGO stage (2018) IA1 (with lymph vascular space invasion), IA2, IB1, IB2 or IIA1 disease
Preoperative histologically confirmed primary adenocarcinoma, squamous cell carcinoma or adenosquamous carcinoma of the uterine cervix
Age 65 years old
Physical grading: Karnofsky score 60 points
Initial treatment
Voluntarily joined the study, signed informed consent, willing to comply, and cooperative with follow-up; (Note: The maximum diameter of the cervical lesion is subject to MRI measurements)

Exclusion Criteria

Patients with contraindications to surgery
Unable or unwilling to sign informed consent
Unable or unwilling to comply with research requirements
Patients who have previously received pelvic/abdominal radiation or chemotherapyPatients who had received radiotherapy and chemotherapy for other cancers in the past
Patients with evidence of extra cervical metastases by CT, MRI or PET
Patients with diameter of lymph node metastasis 2 cm by preoperative MRI
Patients with pregnancy
Patients requiring fertility-preserving surgery
Patients who had previously received subtotal hysterectomy
Patients participating in other clinical trials
Patients with other reasons not suitable clinical trials identified by researchers
Exclusion Criteria for Postoperative Patients
Postoperative pathology: endometrioid adenocarcinoma, clear cell carcinoma, special type adenocarcinoma, neuroendocrine carcinoma (small cell carcinoma), tuberculosis
Postoperative tumor size 4 cm
Patients with abdominal aortic lymph node metastasis
Patients with severe postoperative complications that are not suitable for adjuvant therapy and affect patient follow-up
Patients who did not follow requirements for various reasons (except for various complications and deaths caused by tumor recurrence and metastasis)
Situation which researchers believe that treatment should be terminated
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