Effectiveness of Autologous Adipose-derived Stem Cells in the Treatment of Knee Cartilage Injury

  • STATUS
    Recruiting
  • days left to enroll
    69
  • participants needed
    30
  • sponsor
    Qilu Hospital of Shandong University
Updated on 8 February 2022
cancer
osteoarthritis
osteotomy
intra-articular injection
sodium hyaluronate
treatment of knee

Summary

This study was aimed to evaluate the efficacy and safety of Autologous Adipose-derived Mesenchymal Stem Cell Gel combine with High tibial osteotomy therapy in the treatment of cartilage damage in the knee. Investigator believe that this method will enable patients to recover better knee function and more repair of knee cartilage.

Description

The patients who will underwent high tibial osteotomy were randomly divided into the experimental group and the control group. Abdominal fat extraction before operation in experimental group to prepare Adipose-derived Mesenchymal Stem Cell Gel, while the control group only underwent high tibial osteotomy. One month after operation, the experimental group was injected with Adipose-derived Mesenchymal Stem Cell Gel into the joint cavity, and the control group was injected with sodium hyaluronate in the joint cavity. Two groups of patients were followed up.

Details
Condition Knee Osteoarthritis, Cartilage Degeneration
Treatment Sodium Hyaluronate, Autologous Adipose-derived Mesenchymal Stem Cell Gel, Extraction of abdominal fat
Clinical Study IdentifierNCT03955497
SponsorQilu Hospital of Shandong University
Last Modified on8 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Aged 18-65 years, male and female, patient can tolerate surgery
Clinical diagnosis of degenerative arthritis by Radiographic Criteria
Obviously extra-articular malformation
Good contralateral interventricular cartilage
Course of disease six months
There was no obvious abnormality in tumor marker detection,or patient was evaluated has not at the risk of cancer
Subjects who understand and sign the consent form for this study

Exclusion Criteria

Acute joint injury
Patients with severe primary diseases, such as cardiovascular,cerebrovascular, liver, kidney and hematopoietic system, and psychosis
Cancer patients
Women who are pregnant or breast feeding,or allergic constitution patient
Positive serology for HIV-1 or HIV-2, Hepatitis B (HBsAg, Anti-Hepatitis C virus -Ab), Hepatitis C (Anti-hepatitis C virus -Ab) and syphilis
Receive other open surgery related to knee operation within 6 months
Participation in another clinical trial
Failing to comply with the inclusion criteria, unwilling to comply with the research approach, or incomplete data affecting the curative effect or safety judgment
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