A Study to Evaluate the Safety Tolerability and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis

  • STATUS
    Recruiting
  • End date
    Nov 5, 2029
  • participants needed
    142
  • sponsor
    Biogen
Updated on 27 July 2021
Investigator
Biogen
Primary Contact
Research Site (1.9 mi away) Contact
+71 other location
interferon
relapsing multiple sclerosis
magnetic resonance imaging brain

Summary

This study will evaluate the safety, tolerability, and descriptive efficacy of BIIB017 in pediatric participants with relapsing-remitting multiple sclerosis (RRMS) and to assess the pharmacokinetics (PK) of BIIB017 in pediatric participants with RRMS in Part 1. In Part 2, the study will evaluate the long-term safety of BIIB017 and further describe safety and the long-term multiple sclerosis (MS) outcomes after BIIB017 treatment in participants who completed the study treatment at Week 96 in Part 1 of the study.

Details
Condition relapsing-remitting multiple sclerosis
Treatment BIIB017 (peginterferon beta-1a), Interferon beta type 1a
Clinical Study IdentifierNCT03958877
SponsorBiogen
Last Modified on27 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Part 1
Must have a diagnosis of RRMS as defined by the revised consensus definition for pediatric MS
Must have an EDSS score between 0.0 and 5.5
Must have experienced >= 1 relapse in the 12 months prior to randomization (Day 1) or >= 2 relapses in the 24 months prior to randomization (Day 1) or have evidence of asymptomatic disease activity (Gd-enhancing lesions) on brain MRI in the 6 months prior to randomization (Day 1)
Part 2
Participants who completed the study treatment in Part 1 (Week 96 Visit), as
per protocol

Exclusion Criteria

Part 1
Primary progressive, secondary progressive, or progressive relapsing. These conditions require the presence of continuous clinical disease worsening over a period of at least 3 months. Participants with these conditions may also have superimposed relapses but are distinguished from relapsing participants by the lack of clinically stable periods or clinical improvement
History of severe allergic or anaphylactic reactions or known drug hypersensitivity
Known allergy to any component of Avonex or BIIB017 formulation
Occurrence of an MS relapse that has occurred within 30 days prior to randomization (Day 1) and/or the participant has not stabilized from a previous relapse prior to randomization (Day 1)
Any previous treatment with PEGylated human IFN -1a
Part 2
Any significant changes in medical history occurring after enrollment in Part 1, including laboratory test abnormalities or current clinically significant conditions that, in the opinion of the Investigator, would have excluded the participant's participation in Part 1. The Investigator must re-assess the participant's medical fitness for participation and consider any factors that would preclude treatment
The participant could not tolerate BIIB017 in Part 1
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply
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