Last updated on August 2019

A Study of LY3454738 in Healthy Participants and Participants With Atopic Dermatitis

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Age: Between 18 - 65 Years
  • Gender: Male or Female

Inclusion Criteria:

  • All: Must have a body mass index of 18.0 to 32.0 kilograms per square meter and a minimum body weight of 50 kilograms
  • Japanese: The participant's biological parents and all of the participant's biological grandparents must be of exclusive Japanese descent and must have been born in Japan
  • AD:
  • Must have a diagnosis of AD for at least 12 months with either poor response to topical treatments or inability to use topical treatments
  • Must agree to use moisturizer daily throughout the treatment period

Exclusion Criteria:

  • All: Must not have received study drug in any clinical trial with an agent targeting IL-33 or its receptor
  • AD:
  • Must not have received certain topical medications for AD within 2 weeks prior to randomization
  • Must not have received certain oral medications for AD or received phototherapy within 4 weeks prior to randomization
  • Must not have received any antibody-based biologic agents (marketed or investigational) within 5 half lives (t1/2) of the drug, or dupilumab within 6 months, prior to randomization
  • Must not have received intravenous, intramuscular, or intra-articular steroids in the past 6 weeks prior to randomization

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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