Effects of Brain Stimulation on Higher-Order Cognition

  • STATUS
    Recruiting
  • End date
    Jan 31, 2024
  • participants needed
    120
  • sponsor
    University of California, Davis
Updated on 25 March 2022
transcranial direct current stimulation
antipsychotics
clozapine
schizoaffective disorder
Accepts healthy volunteers

Summary

The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated by transcranial direct current stimulation (tDCS) at frontal and occipital scalp sites. Testing the effects of tDCS at these scalp sites on cognitive task performance will help us understand the roles of the brain regions corresponding to these sites during higher-order cognitive processing (language comprehension, cognitive control, and related attention and memory processes). Behavioral and electrophysiological (EEG) measures will be used to assess cognitive performance. The investigator's overarching hypothesis is that stimulating prefrontal circuits with tDCS can improve cognitive control performance, and ultimately performance on a range of cognitive tasks, as compared to stimulating a different cortical region (occipital cortex) or using sham stimulation. This study is solely intended as basic research in order to understand brain function in healthy individuals and individuals with schizophrenia. This study is not intended to diagnose, cure or treat schizophrenia or any other disease.

Details
Condition Schizophrenia
Treatment Transcranial Direct Current Stimulation
Clinical Study IdentifierNCT03814967
SponsorUniversity of California, Davis
Last Modified on25 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Participants must be able to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks
All subjects must have the ability to give valid informed consent
Inclusion Criteria for Patients with Schizophrenia Only
Diagnosis of schizophrenia, schizophreniform or schizoaffective disorder
No medication changes in the prior month
No medication changes anticipated in the upcoming month
Stable outpatient or partial hospital status
Normal IQ (>70; IQ will be measured by administering the Wechsler Abbreviated Scale of Intelligence (WASI) test)
Must not be currently taking the antipsychotic clozapine

Exclusion Criteria

Pacemakers
Implanted electrical (brain and spinal) stimulators
Implanted defibrillator
Metallic implants
Skin damage or skin conditions such as eczema at the sites where electrodes will be placed
Hair styles hindering the placement of electrodes
Cranial pathologies
Head trauma
Epilepsy
Mental retardation
Any known history of neurological disorders (including epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, cerebral palsy, any DSM-5 axis I psychiatric disorder (for healthy control subjects), autism)
Uncorrected vision problems that would hinder cognitive testing (this also pertains to subjects with color blindness in tasks where discriminating colored objects/items is necessary for successful performance)
Pregnancy
Substance dependence in the past six months
Substance abuse in the past month
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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