Gallium Ga 68-DOTATATE PET/CT in Predicting Tumor Growth in Patients With Meningiomas

  • STATUS
    Recruiting
  • days left to enroll
    68
  • participants needed
    12
  • sponsor
    M.D. Anderson Cancer Center
Updated on 8 February 2022
ct scan
residual tumor
positron emission tomography
dotatate

Summary

This phase I trial studies how well gallium Ga 68-DOTATATE positron emission tomography (PET)/computed tomography (CT) works in predicting tumor growth in patients with meningiomas. Giving Gallium Ga 68-DOTATATE before PET/CT scan may work better in predicting tumor growth in patients with meningiomas.

Description

PRIMARY OBJECTIVES:

I. To assess the ability of imaging with gallium Ga 68-DOTATATE (68Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT).

II. To assess a metabolic response to radiation therapy in meningiomas as measured by a reduction in the tumor to background ratio of the maximum standardized uptake values (SUV) of the tumor compared to background brain parenchyma.

OUTLINE

Patients receive gallium Ga 68-DOTATATE intravenously (IV) over a few minutes and, after 60 minutes, undergo a PET/CT scan over 5-10 minutes 14 days before starting scheduled radiation therapy and 6 weeks after completion of radiation treatment.

Details
Condition Meningioma
Treatment computed tomography, positron emission tomography, Gallium Ga 68-DOTATATE
Clinical Study IdentifierNCT03953131
SponsorM.D. Anderson Cancer Center
Last Modified on8 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Any meningioma with at least 10 mm measurable residual disease
Planned radiation therapy for meningioma
Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria

Neurofibromatosis type 1 or 2
Pregnant
Contraindication to magnetic resonance (MR) imaging
Body weight greater than 400 pounds (lbs) (181.4kg)
Clear my responses

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