Last updated on March 2020

Short or Long Antibiotic Regimes in Orthopaedics

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Ischemic Foot Ulcers | DIABETIC NEUROPATHY | Diabetic Foot | Prosthetic Joint Infection | Foot Ulcer | Osteomyelitis | Diabetic Foot Ulcers
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Provision of informed consent
  2. Aged 18 years or over
  3. Presenting with an orthopaedic infection, defined by one or more of the following
  4. localised pain, OR
  5. localised erythema, OR
  6. temperature 38.0 C, OR
  7. a discharging sinus or wound
  8. Undergoing surgical treatment for the infection
  9. Locally administered antibiotic(s) at the site of orthopaedic infection
  10. Has received <= 7 days of systemic antimicrobial therapy after surgery
  11. Would ordinarily be managed with a prolonged course (>= 4 weeks) of systemic antibiotic(s)
  12. Specimens for microbiological analysis taken at index surgery

Exclusion Criteria:

Surgical exclusion criteria

  1. The index operation was not a definitive procedure with the aim of eradicating
  2. Primary closure has not been achieved, or
  3. Re-look surgery is planned
  4. The index operation involved implant retention (e.g. DAIR)

Microbiological exclusion criteria

3. Any identified micro-organisms from operative specimens from the site of incident infection are fully resistant to the local antibiotic(s) administered at the site of infection

Medical exclusion criteria

4. Other infection necessitating additional systemic antibiotic treatment beyond 7 days after surgery, such as Staphylococcus aureus bacteraemia, psoas abscess, discitis or bacterial endocarditis

5. If the patient is in a clinical trial involving an Investigational Medicinal Product (IMP) related to infection

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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