Identification of Gut Microbiome Biomarkers Associated to Acquisition of Enterobacteriae Highly Resistant to Third Generation Cephalosporines Following Ceftriaxone Treatment. (ARCMI)

  • STATUS
    Recruiting
  • End date
    Oct 19, 2022
  • participants needed
    150
  • sponsor
    Nantes University Hospital
Updated on 7 February 2022

Summary

Patients receiving Ceftriaxone 1 gram or 2 grams per day during their presence in emergency unit of hospital whatever their medical condition, will be included.

Rectal swabs will be collected at inclusion and at days 5 and 30 to perform analysis.

Analysis will be performed to characterize gut microbiome in order to detect intestinal microbiome profiles significantly associated with protection against colonization by third generation cephalosporin resistant Enterobacteriae.

Details
Condition Patients Receiving Ceftriaxone in Hospital Emergency Unit
Treatment Rectal swab collection
Clinical Study IdentifierNCT03569917
SponsorNantes University Hospital
Last Modified on7 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 years
Able to comply with study requirement and to provide informed consent
Outside the context of tutorship and / or guardianship, affiliated to the Social Security Regime and having consented to participate in the ARCMI study
Patient receiving ceftriaxone (1 gram or 2 grams per day) in the emergency department

Exclusion Criteria

Patients with acute anorectal pathology incompatible with the swabbing strategy or digital rectal examination
Prescription of another dosage of ceftriaxone (more than 2 grams per day)
Patient with inflammatory bowel disease
Allergy or contraindication to betalactamines and cephalosporins
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