Last updated on May 2019

A Safety and Efficacy Study of INC280 and Gefitinib in Patients With EGFR Mutated c-MET-amplified NSCLC Who Have Progressed After EGFRi Treatment


Brief description of study

This study will assess the safety and efficacy of escalating doses INC280 when added to gefitinib in patients with lung cancer that are known to have dysregulation of the c-MET pathway and who have failed after benefiting on a prior treatment with either gefitinib or erlotinib.

Detailed Study Description

Patients will be treated INC280 and gefitinib(250mg) daily. Dose escalation for INC280 will be performed. Each cohort for the phase IB part will consist of 3 to 6 newly enrolled patients. A twice daily administration of INC280 may be investigated if deemed appropriate based on emerging results from ongoing clinical trials.

Clinical Study Identifier: NCT01610336

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Novartis Investigative Site

East Bentleigh, Australia
3.15miles
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Recruitment Status: Open


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