Rehabilitation by Eccentric Exercise in Heart Failure Patients

  • End date
    Jul 24, 2022
  • participants needed
  • sponsor
    University Hospital, Clermont-Ferrand
Updated on 24 January 2021


As part of the regular rehabilitation program for chronic heart failure (CHF) patients, the addition of dynamic eccentric endurance (ECC) exercise sessions to the conventional concentric cycling program (CON) would enable greater gains in functional capacity that the CON alone. Furthermore, in the case of severe heart failure, results of conventional exercise rehabilitation remains limited on account of the poor physical fitness and deconditioning. Dynamic ECC has been shown to enhance muscle mass and improve muscle strength in subjects with functional limitations comparable to those in CHF, but to date reports on effects on muscle endurance and overall functional capacity remain scarce or non-existent.

Investigator hypothesize that a combination of these two types of training will allow both an improvement in strength and oxidative muscle capacities. These benefits must be objectified at the level of the walking distance covered in 6 min (6-WT).


Investigator hypothesize that the combination of CON and ECC forms of endurance exercise will potentiate peripheral muscle and cardio-circulatory adaptations. All sessions, regardless of the modality, will be performed at the same percentage of the concentric peakVO2. Sessions performed in ECC mode will induce a mechanical overload. The ECC training of such intensity and duration seemingly having little or no effect on mitochondrial muscle adaptations, the maintenance of conventional training will allow stimulation of the aerobic endurance component. A synergistic effect is expected from the combination of the two modalities; the muscle strength gain induced by ECC allowing to sustained greater cycling workloads yet compatible with the cardio-circulatory capabilities of patients with CHF and more specifically their exercise cardiac output adjustment.

Investigator chose to assess the extent of benefits through functional capacity tests reflecting adaptation of both the aerobic (endurance capacity) and anaerobic (muscle strength) components of adaptive response, namely, 1) 6 min. walk test (6-WT), 2) time up and go test (TUGT), 3) quadriceps isometric muscular strength (IMS) and gait speed test.

The study is a prospective, open, controlled and randomized study in two parallel groups carried out in a single center. Patients will be included in the study if: i) they are referred to the cardiac rehabilitation center for the 5-week training program, ii) they meet the inclusion criteria and iii) they provide their signed consent.

Patients will be followed for 5 weeks, the duration of the cardiac rehabilitation program. They will benefit from the standard evaluation of any CHF patient referred for rehabilitation including an initial 12-lead ECG, a trans-thoracic cardiac ultrasound assessment and a cycling exercise stress test with gas exchange analysis and non-invasive measurement of cardiac output using a bio-impedance device. A standard biological blood analysis will be performed for NFS-platelets, blood electrolytes, CRP, NTproBNP, nutritional status with albumin and pre-albumin.

All subjects will perform 5 exercise sessions per week on a cycle ergometer. As per randomization outcome, the "intervention" group will perform three of the five weekly sessions in ECC mode (the other two in CON) while the control group will perform the five weekly sessions in CON mode.

The intensity of the cycling will be the same in both groups as determined from the initial cycling incremental test targeted to correspond to the VO2 associated with the ventilatory threshold.

Condition Rehabilitation, Chronic Heart Failure Patient, rehabilitation program, rehabilitation therapy, rehabilitation treatment, therapy rehabilitation, rehabilitations
Treatment Eccentric rehabilitation sessions
Clinical Study IdentifierNCT03716778
SponsorUniversity Hospital, Clermont-Ferrand
Last Modified on24 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 75 yrs?
Gender: Male or Female
Do you have any of these conditions: Chronic Heart Failure Patient or Rehabilitation?
Do you have any of these conditions: therapy rehabilitation or Chronic Heart Failure Patient or rehabilitation program or rehabilitation treatment or rehabilitation therapy or Rehabilitat...?
Patient with systolic chronic heart failure
Patients aged 18 to 75 years
Referred for participation in the 5-week rehabilitation program
At a time distance from an acute coronary syndrome or myocarditis (less than 3 months old) and clinically stabilized
Beneficiary or affiliated with social security coverage

Exclusion Criteria

All the usual criteria considered contra-indicated for cardiac exercise rehabilitation according to the consensus recommendations ( REF)
Non-stabilized acute coronary syndrome
Decompensated heart insufficiency
Severe, uncontrolled disturbances in ventricular rhythm
Presence of an intracardiac thrombus with high risk of embolism
Presence of pericardial effusion of medium to high importance
Recent history of thrombophlebitis with or without pulmonary embolism
Obstacle to severe and / or symptomatic left ventricular ejection
Any progressive inflammatory and / or infectious condition
Severe and symptomatic pulmonary arterial hypertension
Inability to perform physical activity
Reversible heart disease
Patients undergoing circulatory assistance
Patients taking blood thinner medication (except Kardegic-type aggregates and direct oral anticoagulants)
Patients with known allergy to Xylocaine
Pregnant or lactating women
Women of childbearing age without contraception
Patient under tutorship, curatorship or deprived of liberty
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