Innovative Biomarkers in de Novo Parkinson's Disease

  • End date
    Apr 24, 2024
  • participants needed
  • sponsor
    University Hospital, Grenoble
Updated on 26 March 2021
movement disorder
muscle rigidity
resting tremor


This study aims at identifying potential new and innovative biomarkers in de novo Parkinson's disease patients. New finding will help phenotyping patients since the diagnosis of the disease and potentially also in the preclinical phase.


The investigators will use 4 different approaches in parallel:

  1. detailed clinical evaluation using the current available validated clinical scales and the Dopamine transporter (DAT) SPECT imaging;
  2. anatomical and perfusional brain evaluation using functional MRI;
  3. cortical brain mapping and transcranial magnetic stimulation assessment using a robotized approach;
  4. emotional responses study using a novel paradigm. These 4 modalities will be assessed at baseline, 1 year and 2 years follow-up.

The investigators will integrate these 4 analysis using a mathematical paradigm in order to define specific phenotype of disease and disease progression.

Condition Parkinson's disease, Healthy Controls Group - Age and Sex-matched, Healthy Controls Group - Age and Sex-matched, parkinson's, parkinson disease, Healthy Controls Group - Age and Sex-matched, Healthy Controls Group - Age and Sex-matched, Healthy Controls Group - Age and Sex-matched
Treatment Brain MRI, TMS-EEG, Behavioral and cognitive battery, Clinical evaluation and clinical scales
Clinical Study IdentifierNCT03940677
SponsorUniversity Hospital, Grenoble
Last Modified on26 March 2021


Yes No Not Sure

Inclusion Criteria

Parkinson's disease
Asymmetric bradykinesia and/or resting tremor and rigidity since less than 2.5 years
Hoehn & Yahr 2/5
Montreal cognitive assessment 26/30

Exclusion Criteria

Treatment for Parkinson's disease (except selegiline and rasagiline)
Severe visual/retinal pathology revealed during ophthalmological assessment
Hyper-sensibility to gadolinium
Renal failure
Specific MRI contraindication
Specific TMS contraindication
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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