Summit is developing ridinilazole as a novel antimicrobial for Clostridium difficile
Infection (CDI) with the goal of achieving comparable cure rates to standard of care, but
reducing rates of recurrent disease.
A phase 2 proof of concept study, with vancomycin as comparator, demonstrated these
attributes with a comparable safety profile. A high fecal concentration of ridinilazole and
little systemic exposure were noted.
The rationale for this phase 3 study is to confirm the improvement in sustained clinical
response of CDI over vancomycin and to compare the safety and tolerability of ridinilazole to
that of vancomycin.
Clinical Study Identifier
Last Modified on
8 July 2020
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