Prevalence of PD-L1 Expression in Patients With Advanced Urothelial Carcinoma

  • STATUS
    Recruiting
  • End date
    Jun 7, 2023
  • participants needed
    179
  • sponsor
    AstraZeneca
Updated on 20 June 2021
Investigator
AstraZeneca Clinical Study Information Center
Primary Contact
Research Site (2.2 mi away) Contact
+67 other location
systemic therapy
platinum-based chemotherapy
advanced urothelial carcinoma
chemoradiation

Summary

The purpose of this study is to assess the prevalence of pre-treatment tumor tissue PD-L1 expression in patients diagnosed with advanced urothelial carcinoma.

Description

Advanced urothelial carcinoma (UC) (locally advanced/unresectable or metastatic UC) is a fatal disease with 5-year survival rate of 5%. The most frequently studied diagnostic for advanced UC is the programmed death-ligand 1 (PD-L1) protein expression in tumor tissue. A better understanding of PD-L1 expression in a "real world" setting could help understand its clinical utility in the management and decision making in advanced UC and clinical trial design

Details
Condition Transitional cell carcinoma, Urothelial Carcinoma
Clinical Study IdentifierNCT03788746
SponsorAstraZeneca
Last Modified on20 June 2021

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