Anthracycline Induced Cardiotoxicity - Early Detection by Combination of Diastolic Strain and T2-mapping

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    130
  • sponsor
    Heinrich-Heine University, Duesseldorf
Updated on 23 January 2021
cancer
heart failure
early detection
breast cancer
doxorubicin
anthracyclines
strain
cancer treatment
cardiac mri
breast cancer, treatment

Summary

Anthracyclines (e.g. Doxorubicin) are an important and highly effective chemotherapeutic. They are used in various tumor entities and are established for breast cancer treatment. The most significant prognostic side effect is cardiotoxicity, which occurs in up to 50 patients. Female gender must be considered an independent risk factor for the incidence and severity of associated heart failure. The aim of this study is to demonstrate that dose-dependent anthracycline-induced cardiotoxicity has a measurable effect on T2 mapping on MRI. The second aim is to demonstrate if the combination of diastolic strain (echo and MRI) and T2 mapping can detect earlier anthracycline-induced myocardial damage than via the established method of the echocardiographic measurement of LV-EF and the conventional quantification of diastolic function.

Description

In order to answer the question, patients with breast cancer, who will undergo a chemotherapeutic treatment with antracycline, will be examined before chemotherapy (including cmr and echocardiography) and after chemotherapy at different times within one year.

Details
Condition Breast Cancer, Diet and Nutrition, Chronic Diarrhea, Skin Wounds, Chronic Shoulder Pain, Vaginal Atrophy, Adverse Effects, Drugs, Injection Port, Breast Cancer - HER2 Positive, Anal Dysplasia, Primary Immunodeficiency, Pediatric Health, Near-Sighted Corrective Surgery, Cardiotoxicity, Peripheral Arterial Occlusive Disease, Breast Cancer Diagnosis, Brain Function, Cardiac Toxicity, Recurrent Respiratory Papillomatosis, Razor Bumps (Pseudofolliculitis Barbae), Metastatic Triple-Negative Breast Cancer, Myocardial Damage, breast carcinoma, cancer, breast
Treatment Cardiac MRI and echocardiography, laboratory parameters
Clinical Study IdentifierNCT03940625
SponsorHeinrich-Heine University, Duesseldorf
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Planned therapy with an anthracycline and at least 1 year follow up
>18 years of age
written informed consent

Exclusion Criteria

prior cardiovascular disease
diabetes mellitus
previous therapy with anthracyclines
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