Anthracycline Induced Cardiotoxicity - Early Detection by Combination of Diastolic Strain and T2-mapping (ANKE)

    Not Recruiting
  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Heinrich-Heine University, Duesseldorf
Updated on 2 June 2022
heart failure
early detection
breast cancer
cancer treatment
cardiac mri
breast cancer, treatment


Anthracyclines (e.g. Doxorubicin) are an important and highly effective chemotherapeutic. They are used in various tumor entities and are established for breast cancer treatment. The most significant prognostic side effect is cardiotoxicity, which occurs in up to 50 patients. Female gender must be considered an independent risk factor for the incidence and severity of associated heart failure. The aim of this study is to demonstrate that dose-dependent anthracycline-induced cardiotoxicity has a measurable effect on T2 mapping on MRI. The second aim is to demonstrate if the combination of diastolic strain (echo and MRI) and T2 mapping can detect earlier anthracycline-induced myocardial damage than via the established method of the echocardiographic measurement of LV-EF and the conventional quantification of diastolic function.


In order to answer the question, patients with breast cancer, who will undergo a chemotherapeutic treatment with antracycline, will be examined before chemotherapy (including cmr and echocardiography) and after chemotherapy at different times within one year.

Condition Breast Cancer, Myocardial Damage, Cardiotoxicity
Treatment Cardiac MRI and echocardiography, laboratory parameters
Clinical Study IdentifierNCT03940625
SponsorHeinrich-Heine University, Duesseldorf
Last Modified on2 June 2022

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