Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers

  • STATUS
    Not Recruiting
  • participants needed
    28
  • sponsor
    University Hospital, Basel, Switzerland
Updated on 17 June 2021

Summary

This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.

Description

Copeptin measurements upon intravenous arginine stimulation discriminate patients with diabetes insipidus versus patients with primary polydipsia with a high diagnostic accuracy. An oral test would be easier to perform, causes less risks and discomfort for the patients and would require less resources in clinical practice. This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.

Details
Condition Polyuria-polydipsia Syndrome, Polyuria-polydipsia Syndrome
Treatment Macimorelin 0.5mg/kg body weight, Macimorelin 0.75mg/kg body weight
Clinical Study IdentifierNCT03844217
SponsorUniversity Hospital, Basel, Switzerland
Last Modified on17 June 2021

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