This Study Tests the Safety of Inhaled BAY1237592, How the Drug is Tolerated and How it Effects Patients With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) (ATMOS)

  • STATUS
    Not Recruiting
  • End date
    Apr 5, 2023
  • participants needed
    56
  • sponsor
    Bayer
Updated on 14 September 2022
nitric oxide
prostaglandin
pulmonary arterial hypertension
right heart catheterization
endothelin
iloprost
chronic thromboembolic pulmonary hypertension
endothelin receptor antagonist

Summary

In this trial the effects of the inhaled drug BAY1237592 will be studied in patients with high blood pressure in the pulmonary blood vessels due to Pulmonary Arterial Hypertension (PAH) and due to Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Pulmonary hypertension is characterized by the elevation of pressure in the pulmonary arteries (PAP) and of the pulmonary vascular resistance (PVR) leading to increased workload of the right chamber of the heart to eject blood against this elevated resistance. The goal of this study is to measure the safety and tolerability of the drug as well as the reduction of the PVR at different doses

In Part A patients without specific treatment for PH (untreated patients) will be tested. In Part B also patients stably pre-treated with specific PH drugs will be studied in combination with the new inhaled drug

Details
Condition Hypertension, Pulmonary
Treatment BAY1237592, NO gas, PH-monotherapy, PH-combination therapy
Clinical Study IdentifierNCT03754660
SponsorBayer
Last Modified on14 September 2022

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