A Study of Lorlatinib in ALK Inhibitor-Treated ALK-Positive NSCLC in China

  • End date
    Aug 10, 2022
  • participants needed
  • sponsor
Updated on 25 February 2021
kinase inhibitor
serum bilirubin level
neutrophil count
follicle stimulating hormone
cancer chemotherapy
kidney function test
lung carcinoma
secondary malignant neoplasm of liver


A Phase 2, multi center, open label, dual cohort study to evaluate the efficacy and safety of lorlatinib (PF 06463922) monotherapy in ALK inhibitor treated locally advanced or metastatic ALK positive non small cell lung cancer patients in China


This is a Phase 2, China only, multi center, open label, dual cohort study, in ALK positive locally advanced or metastatic NSCLC patients will be enrolled to receive lorlatinib monotherapy.

  • (in Cohort 1) Disease progression after crizotinib as the only ALK inhibitor.
  • (in Cohort 2) Disease progression after one ALK inhibitor other than crizotinib.

Condition Non-Small Cell Lung Cancer
Treatment Lorlatinib
Clinical Study IdentifierNCT03909971
Last Modified on25 February 2021


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