Pembrolizumab and Exemestane/ Leuprolide in Premenopausal HR+/ HER2- Locally Advanced or Metastatic Breast Cancer (PEER)

  • STATUS
    Recruiting
  • participants needed
    25
  • sponsor
    National Taiwan University Hospital
Updated on 6 February 2023

Summary

This is an open-label, single-arm, multicenter, pilot study of pembrolizumab, exemestane, and leuprolide for subjects being resistant for front-line hormonal therapy for inoperable locally advanced or metastatic hormonal receptor positive (HR+)/ Human epidermal growth factor receptor 2 (HER2) negative breast cancer. All the patients will be included in the final tolerability and preliminary efficacy analysis. The efficacy objectives including PFS, overall response rate (ORR), clinical benefit rate (CBR), and duration of response (DOR). Adverse effects will be recorded according to CTCAE v4.0.

Details
Condition Premenopausal Breast Cancer
Treatment Pembrolizumab/ Exemestane/ Leuprolide
Clinical Study IdentifierNCT02990845
SponsorNational Taiwan University Hospital
Last Modified on6 February 2023

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