This is an open-label, single-arm, multicenter, pilot study of pembrolizumab, exemestane, and leuprolide for subjects being resistant for front-line hormonal therapy for inoperable locally advanced or metastatic hormonal receptor positive (HR+)/ Human epidermal growth factor receptor 2 (HER2) negative breast cancer. All the patients will be included in the final tolerability and preliminary efficacy analysis. The efficacy objectives including PFS, overall response rate (ORR), clinical benefit rate (CBR), and duration of response (DOR). Adverse effects will be recorded according to CTCAE v4.0.
| Condition | Premenopausal Breast Cancer |
|---|---|
| Treatment | Pembrolizumab/ Exemestane/ Leuprolide |
| Clinical Study Identifier | NCT02990845 |
| Sponsor | National Taiwan University Hospital |
| Last Modified on | 25 March 2023 |
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