Improving Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease

  • STATUS
    Recruiting
  • End date
    Jan 8, 2023
  • participants needed
    48
  • sponsor
    Virginia Commonwealth University
Updated on 8 August 2022
bronchodilator
Accepts healthy volunteers

Summary

Researchers have found a link between chronic obstructive pulmonary disease (COPD) and heart disease; however, a link is all they have found. Cardiovascular health in COPD is controlled by different mechanisms including vascular health and systemic inflammation. The investigators have collected preliminary data to support that concentrations of Sirtuin 1 (Sirt1), a protein that plays a key role in cardioprotection, may be involved in cardiovascular health in patients with COPD. Resveratrol, an over the counter natural polyphenol found in a variety of food, is a direct activator of Sirt1 and has been used to improve cardiovascular health in different cohorts. The current project is an attempt to expand previous findings and explore the effects of the sub-chronic use of resveratrol in sustaining the improvements in cardiovascular health in COPD.

Description

The present study is designed as a double-blind, randomized, cross-over, placebo-controlled protocol. Patients with COPD will receive either resveratrol (500 mg) or placebo for 12 weeks. A comprehensive evaluation of cardiovascular health will be performed. Results will provide novel insights into the mechanistic role that Sirt1 mediates in COPD related vascular dysfunction and systemic inflammation.

Details
Condition Chronic Obstructive Pulmonary Disease
Treatment Placebo, Resveratrol
Clinical Study IdentifierNCT03819517
SponsorVirginia Commonwealth University
Last Modified on8 August 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Participants with a clinical diagnosis of COPD known for at least one year will be allowed to participate
Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages II to IV
Breathing test ratio (FEV1/FVC) <0.7
Amount of exhaled air (FEV1) <80% predicted after bronchodilator
Total Lung Capacity (TLC)>80%
Matched healthy volunteers without COPD

Exclusion Criteria

FEV1/FVC>0.7
Clinical diagnosis of heart disease, hypertension or diabetes
Use of vasoactive medications (nitrates, Beta blockers)
Uncontrolled high blood pressure
Pulmonary hypertension
Fluid in the lungs
Sleep apnea
Thyroid problems
Anemia
Raynaud's phenomenon
Gastrointestinal bleeding
History of coagulopathies
History of low platelets
Gangrene of the digits
Phenylketonuria
Pregnant or women attempting to become pregnant
In lactation
Individuals who may not be able to read or understand the resveratrol label
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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