Preoperative Antibiotics for Carpal Tunnel Release Surgery

  • End date
    Dec 26, 2023
  • participants needed
  • sponsor
    WellSpan Health
Updated on 26 January 2021
carpal tunnel release


This is a clinical trial to determine how effective antibiotics administered prior to endoscopic carpal tunnel release surgery are in preventing surgical site infections.


Study participants will be randomized to a prophylactic IV antibiotic treatment arm (Vancomycin or Cefazolin) or a placebo IV saline solution. Subjects will be monitored following surgery for surgical site infections.

Condition Carpal Tunnel Syndrome
Treatment Vancomycin, Cefazolin, Saline solution
Clinical Study IdentifierNCT03432858
SponsorWellSpan Health
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

High probability (>12 points) on the Carpal Tunnel-6 diagnostic aide
Recommendation for carpal tunnel release
Capable of providing informed consent/LAR to act on subject's behalf

Exclusion Criteria

Patients allergic to both penicillin/cephalosporins and vancomycin
Patient immobilized with splint or cast
Unwilling unable to provide informed consent
Children under the age of 18
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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