Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for Endometrial Carcinoma (ENGOT-en9 / MK-7902-001)

  • STATUS
    Recruiting
  • End date
    Apr 10, 2023
  • participants needed
    720
  • sponsor
    Merck Sharp & Dohme Corp.
Updated on 31 March 2021
Investigator
Toll Free Number
Primary Contact
Royal North Shore Hospital ( Site 1600) (4.8 mi away) Contact
+215 other location
paclitaxel
carcinoma
carboplatin
hormone therapy
pembrolizumab
solid tumour
mk-3475
endometrial carcinoma
recurrent endometrial cancer

Summary

The purpose of this study is to compare the efficacy of pembrolizumab + lenvatinib to chemotherapy in female participants with Stage III, IV, or recurrent endometrial carcinoma. It is hypothesized that the combination of pembrolizumab + lenvatinib will be superior to chemotherapy for progression-free survival (PFS) per Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST 1.1) by blinded independent central review (BICR). It is also hypothesized that the combination of pembrolizumab + lenvatinib will be superior to chemotherapy for overall survival (OS).

Details
Condition Endometrial Carcinoma, Uterine Cancer, Endometrial Cancer
Treatment carboplatin, Paclitaxel, Pembrolizumab, Lenvatinib
Clinical Study IdentifierNCT03884101
SponsorMerck Sharp & Dohme Corp.
Last Modified on31 March 2021

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