Resveratrol and Vascular Function in CKD

  • days left to enroll
  • participants needed
  • sponsor
    Diana Jalal
Updated on 23 March 2022
type 2 diabetes mellitus
ace inhibitor
angiotensin converting enzyme


The proposed research is clinical study evaluating the therapeutic benefits of resveratrol on vascular function in patients with chronic kidney disease (CKD). The study aims to establish that resveratrol will improve endothelial function and functional performance by reducing oxidative stress and in conjunction with lowering markers of inflammation and oxidative stress.


Patients with chronic kidney disease (CKD) have an exceptionally high risk for cardiovascular disease (CVD), and are 10 times more likely to die from CVD prior to requiring dialysis or kidney transplantation. Inflammation, oxidative stress and vascular dysfunction (impaired endothelial function and increased large elastic artery stiffness), are highly prevalent in CKD and contribute to the high incidence of CVD in this patient population. In addition, patients with CKD suffer from high rates of cognitive decline for which we lack effective therapies. Thus, therapeutic interventions targeting inflammation, oxidative stress, vascular dysfunction in CKD are a priority.

Wine intake, which is known to be rich in various polyphenolic compounds, might have a variety of health benefits. Among these polyphenols, the stilbene derivative resveratrol (RSV), a naturally occurring polyphenol found in grapes and red wine, has recently come to light, as it has been shown to exert potent anti-diabetic, anti-oxidative and anti-inflammatory actions. Importantly, recent studies have demonstrated that resveratrol is well-tolerated (37) and may confer similar benefits in individuals at high risk of CVD, such as improved endothelial function in individuals with metabolic syndrome (i.e. diabetes)

The primary goal of this application is to determine whether 6 wks resveratrol (RSV) supplementation improves vascular function by reducing oxidative stress in a randomized, double-blind, cross-over study of 25 patients with diabetic kidney disease. The investigators hypothesize that: 1) 6 wks RSV will improve vascular function as measured via BA-FMD vs. placebo and 2) that the improvement in vascular function will be related, at least partially, to a reduction in oxidative stress.

Condition Chronic Kidney Diseases, Endothelial Dysfunction
Treatment Placebo, Resveratrol
Clinical Study IdentifierNCT03597568
SponsorDiana Jalal
Last Modified on23 March 2022


Yes No Not Sure

Inclusion Criteria

CKD stage III (estimated GFR: 30-60 mL/MIN/1.73m2)
Able to give informed consent
Angiotensin converting enzyme inhibitor or angiotensin II receptor bloocker for > 3 month prior to the study
Type II diabetes mellitus

Exclusion Criteria

Consuming > 2 glasses/day red wine and/or taking resveratrol or vitamin C supplement in the past 12 months
Life expectancy <1 year
BMI >40 kg/m2 1
Pregnant, breastfeeding, or unwilling to use adequate birth control
Uncontrolled hypertension; blood pressure > 140/90
Uncontrolled type II DM; AIC > 8.5
Currently taking anticoagulants including: coumadin, dalteparin, enoxaparin, haparin, and plavix
Severe liver disease
Severe systolic heart failure
Hospitalization within the last 3 months
Active infection or antibiotic therapy
Immunosuppressive therapy within the last year
Currently partaking in another research study
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