Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot Study

  • STATUS
    Recruiting
  • End date
    May 31, 2022
  • participants needed
    35
  • sponsor
    Medical University of Vienna
Updated on 18 September 2021
optical coherence tomography
brimonidine tartrate ophthalmic solution
ametropia
macular degeneration
pigmentary glaucoma
primary open angle glaucoma

Summary

It has been shown that reactions of human retinal photoreceptors to a light stimulus can be measured with custom-made, research prototype optical coherence tomography (OCT) systems. This can be used as a biomarker for the function of the photoreceptors. Due to the high technical demands on the system, however, the technique is currently not available for clinical purposes. In this pilot study a protocol to measure changes in retinal photoreceptor layer thickness before and after light stimulation shall be developed based on a commercial OCT system and newly developed algorithms. Other variables, such as circadian processes shall be investigated as well. After measurements in healthy volunteers, the protocol is planned to be applied in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) to test for feasibility of the method in these patient groups.

Details
Condition Glaucoma, Pigmentary glaucoma, Open Angle Glaucoma, Primary Open Angle Glaucoma, Dry Macular Degeneration, Geographic Atrophy
Treatment White light stimulation
Clinical Study IdentifierNCT03921931
SponsorMedical University of Vienna
Last Modified on18 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

men and women aged over 18 years
signed informed consent form
ametropia below 3 diopters
ability and willingness to follow instructions
for healthy volunteers
normal ophthalmologic findings
for primary open angle glaucoma patients (POAG)
diagnosed POAG
MD <= 10 dB
for age-related macular degeneration (AMD)
diagnosed dry AMD
diagnosed stage II or stage III AMD

Exclusion Criteria

Presence of any abnormalities preventing reliable measurements
Ocular inflammation and ocular disease interfering with the study aims
Use of photosensitizing medication (phototoxic drugs, photoallergic drugs) in the 3 months preceding the study
Presence of any condition with the possibility of causing photosensitivity, including systemic lupus erythematosus SLE, Porphyria, Vitiligo, Xeroderma Pigmentosum and Albinism
Presence of any form of epilepsy
Ocular surgery in the 3 months preceding the study
Pregnancy, planned pregnancy or lactating
Any medical or surgical history, disorder or disease such as acute or chronic severe organic disease
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

0/250

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note