A Study to Evaluate Safety, Tolerability and Preliminary Efficacy of FP-1305 in Cancer Patients (MATINS)
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- STATUS
- Recruiting
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- End date
- Nov 30, 2024
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- participants needed
- 700
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- sponsor
- Faron Pharmaceuticals Ltd
Summary
This is a first in human study to identify whether FP-1305 is suitable to use in humans. The previous pre-clinical studies have demonstrated that FP-1305 binds to a receptor known as CLEVER-1. CLEVER-1 has been shown to support tumour growth. No significant adverse events were witnessed in primates and the dose used will be 300 fold lower than the dose provided to primates which showed no toxicity.
The patients with advanced melanoma, uveal melanoma, cholangiocarcinoma, gallbladder cancer, ER+ breast, gastric, ovarian, pancreatic, colorectal, liver or anaplastic thyroid cancer who have exhausted all licenced therapeutic options will die due to their disease. Based on the investigator's existing data CLEVER-1 is expressed in these tumour types. Inhibition of CLEVER-1 with FP-1305 may have an anti-tumour effect in these patients.
Details
| Condition | Cancer |
|---|---|
| Treatment | FP-1305 |
| Clinical Study Identifier | NCT03733990 |
| Sponsor | Faron Pharmaceuticals Ltd |
| Last Modified on | 6 June 2022 |
Eligibility
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