A Study to Evaluate Safety Tolerability and Preliminary Efficacy of FP-1305 in Cancer Patients

  • STATUS
    Recruiting
  • End date
    Nov 30, 2024
  • participants needed
    650
  • sponsor
    Faron Pharmaceuticals Ltd
Updated on 1 August 2021
platelet count
measurable disease
carcinoma
breast cancer
bone marrow procedure
metastasis
neutrophil count
pd-l1
primary cancer
adenocarcinoma
exhaustion

Summary

This is a first in human study to identify whether FP-1305 is suitable to use in humans. The previous pre-clinical studies have demonstrated that FP-1305 binds to a receptor known as CLEVER-1. CLEVER-1 has been shown to support tumour growth. No significant adverse events were witnessed in primates and the dose used will be 300 fold lower than the dose provided to primates which showed no toxicity.

The patients with advanced melanoma, uveal melanoma, cholangiocarcinoma, gallbladder cancer, ER+ breast, gastric, ovarian, pancreatic, colorectal, liver or anaplastic thyroid cancer who have exhausted all licenced therapeutic options will die due to their disease. Based on the investigator's existing data CLEVER-1 is expressed in these tumour types. Inhibition of CLEVER-1 with FP-1305 may have an anti-tumour effect in these patients.

Details
Condition Cancer, Cancer/Tumors, Ewing's Family Tumors, Cancer (Pediatric), Neoplasms, primary cancer, primary malignant neoplasm, malignancy, cancers, malignancies, malignant tumor, malignant tumors
Treatment FP-1305
Clinical Study IdentifierNCT03733990
SponsorFaron Pharmaceuticals Ltd
Last Modified on1 August 2021

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