A Study to Evaluate Safety, Tolerability and Preliminary Efficacy of FP-1305 in Cancer Patients (MATINS) (MATINS)

  • End date
    Nov 30, 2024
  • participants needed
  • sponsor
    Faron Pharmaceuticals Ltd
Updated on 26 July 2022
platelet count
measurable disease
breast cancer
bone marrow procedure
neutrophil count
primary cancer


This is a first in human study to identify whether FP-1305 is suitable to use in humans. The previous pre-clinical studies have demonstrated that FP-1305 binds to a receptor known as CLEVER-1. CLEVER-1 has been shown to support tumour growth. No significant adverse events were witnessed in primates and the dose used will be 300 fold lower than the dose provided to primates which showed no toxicity.

The patients with advanced melanoma, uveal melanoma, cholangiocarcinoma, gallbladder cancer, ER+ breast, gastric, ovarian, pancreatic, colorectal, liver or anaplastic thyroid cancer who have exhausted all licenced therapeutic options will die due to their disease. Based on the investigator's existing data CLEVER-1 is expressed in these tumour types. Inhibition of CLEVER-1 with FP-1305 may have an anti-tumour effect in these patients.

Condition Cancer
Treatment FP-1305, FP-1305 (bexmarilimab)
Clinical Study IdentifierNCT03733990
SponsorFaron Pharmaceuticals Ltd
Last Modified on26 July 2022


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