Last updated on June 2020

Effects of Sodium-glucose Co-transporter-2( SGLT-2 ) Inhibition on Sympathetic Nervous System Activity in Humans


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Type 2 | Diabetes (Pediatric) | Metabolic syndrome | NIDDM | Diabetes Mellitus | Obesity | Metabolic disorder | Diabetes Mellitus Type 2 | Diabetes Prevention | Metabolic Disorders | Diabetes Mellitus Types I and II
  • Age: Between 25 - 65 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Age: 25 -65 years
  • (Body Mass Index) BMI30kg/m2
  • Currently weight stable (+/- 3% in previous 6-12 months and not on any specific exercise or dietary program)
  • Metabolic syndrome (defined as having: obesity (BMI 30kg/m2 ) plus any two of the following four factors: Elevated triglycerides (Triglyceride 1.7mmol/L), Reduced HDL (High - density lipoprotein) cholesterol (<1.0mmol/L in males, <1.3mmol/L in females), Elevated clinic systolic (Blood Pressure) BP 130 or diastolic BP 85mmHg, Fasting glucose 5.6mmol/L or type 2 diabetes.
  • office BP for screening purposes 160/90mmHg
  • drug nave for at least 6 weeks prior to baseline assessment

Exclusion Criteria:

  • Grade 2-3 hypertension (systolic office BP >160, diastolic office BP >100 mmHg)
  • Secondary causes of hypertension
  • CKD (Chronic kidney disease) stage 4-5 {(estimated glomerular filtration) eGFR<30ml/min}
  • Heart failure NYHA (New York Heart Association) class II-IV
  • Recent CV (cardiovascular) event (acute myocardial infarction, acute coronary syndrome, stroke or transient ischaemic attack within the previous six months)
  • unstable psychiatric condition
  • medication such as corticosteroids, several antidepressants and antipsychotics
  • Female participants of childbearing potential must have a negative pregnancy test prior to treatment

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.