Last updated on May 2020

Study Evaluating the Efficacy of Maintenance Olaparib and Cediranib or Olaparib Alone in Ovarian Cancer Patients


Brief description of study

ICON 9 will assess the efficacy, safety and tolerability of maintenance olaparib in combination with cediranib compared to maintenance olaparib alone following a response to platinum-based chemotherapy in women with relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer. Prognostic and predictive factors will be studied from tumour and blood samples.

Detailed Study Description

ICON9 is an international multicentre randomised, phase III trial assessing maintenance treatment with olaparib and cediranib or olaparib alone in women with relapsed ovarian cancer whose disease progressed more than 6 months after first line chemotherapy. Women whose disease responds to platinum chemotherapy following 3 to 4 cycles can be registered for collection of germline BRCA test results if known, and somatic BRCA testing of archival tumour specimens or secondary debulking tissue if required. Patients who have completed treatment and whose disease has responded (partial or complete) to a minimum of 4 cycles of platinum based chemotherapy will be randomised to maintenance treatment of either olaparib and cediranib or olaparib alone.

The maintenance regimen may be continued beyond radiological progression until trial closure if the patient is deemed to still be deriving clinical benefit, but must be discontinued once subsequent treatment is instituted.

Clinical Study Identifier: NCT03278717

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Flinders Medical Centre

Bedford Park, Australia
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Canberra Hospital

Canberra, Australia
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Gosford Hospital

Gosford, Australia
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Westmead Hospital

Westmead, Australia
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Kent & Canterbury Hospital

Canterbury, United Kingdom
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Cheltenham General Hospital

Cheltenham, United Kingdom
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Western General Hospital

Edinburgh, United Kingdom
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Hammersmith Hospital

London, United Kingdom
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The Christie Hospital

Manchester, United Kingdom
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Churchill Hospital

Oxford, United Kingdom
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Queen Alexandra Hospital

Portsmouth, United Kingdom
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Lister Hospital

Stevenage, United Kingdom
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ICON Cancer Centre

South Brisbane, Australia
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Townsville Hospital

Townsville, Australia
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Furness General Hospital

Barrow In Furness, United Kingdom
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Royal Lancaster Infirmary

Lancaster, United Kingdom
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Guy's Hospital

London, United Kingdom
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Singleton Hospital

Swansea, United Kingdom
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Monash Health

Clayton, Australia
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Mater Cancer Centre

South Brisbane, Australia
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Christchurch Hospital

Christchurch, New Zealand
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Royal Berkshire Hospital

Reading, United Kingdom
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Royal Cornwall

Truro, United Kingdom
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Recruitment Status: Open


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