Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)

  • End date
    Sep 17, 2024
  • participants needed
  • sponsor
    Merck Sharp & Dohme Corp.
Updated on 19 September 2021
combination therapy
systemic therapy
measurable disease
breast cancer
growth factor
squamous cell carcinoma
steroid therapy
cytotoxic chemotherapy
epidermal growth factor receptor
programmed cell death 1 ligand 1
human epidermal growth factor
solid tumour
solid tumor
triple negative breast cancer
progesterone receptor
epidermal growth factor
estrogen receptor
fallopian tube
bladder cancer
line of therapy
biliary cancer
extrahepatic cholangiocarcinoma
metastatic pancreatic cancer
biliary tract cancer
cancer vaccine
colorectal neoplasm
pancreatic cancers
combined modality therapy
cancer of the ovary
stereotactic biopsy
pancreatic ductal adenocarcinoma
breast ductal carcinoma


The purpose of this study is to determine the safety and efficacy of combination therapy with pembrolizumab (MK-3475) and lenvatinib (E7080/MK-7902) in participants with triple negative breast cancer (TNBC), ovarian cancer, gastric cancer, colorectal cancer (CRC), glioblastoma (GBM), biliary tract cancers (BTC), or pancreatic cancer.

Condition Pancreatic Cancer, Ovarian disorder, Colorectal Cancer, Rectal disorder, Pancreatic disorder, Breast Cancer, Biliary neoplasm, Ovarian Cancer, Glioblastoma Multiforme, Neoplasm of unspecified nature of digestive system, Gastropathy, Gastric Cancer, Diet and Nutrition, Chronic Diarrhea, Stomach Discomfort, Pancreatic Disorders, Skin Wounds, Chronic Shoulder Pain, Vaginal Atrophy, Adverse Effects, Drugs, Injection Port, Breast Cancer - HER2 Positive, Anal Dysplasia, Primary Immunodeficiency, Pediatric Health, Near-Sighted Corrective Surgery, Colon Cancer Screening, Rectal Disorders, Colon cancer; rectal cancer, Ovarian Function, Advanced Solid Tumors, Peripheral Arterial Occlusive Disease, Triple Negative Breast Cancer, Brain Function, Gastric Carcinoma, Recurrent Respiratory Papillomatosis, Recurrent Ovarian Cancer, Razor Bumps (Pseudofolliculitis Barbae), Urothelial Tract Cancer, Islet Ce417ll Cancer, Metastatic Triple-Negative Breast Cancer, Stomach Cancer, Biliary Tract Cancer, Digestive System Neoplasms, colorectal neoplasm, glioblastoma, ovarian carcinomas, cancer, ovarian, cancer ovarian, cancer of the ovary, gastric cancers, colorectal cancers, cancer of the pancreas, ovarian tumors, pancreatic cancers, cancer, pancreatic, cancer, colorectal, colorectal tumor, tumors, colorectal, biliary cancer
Treatment Pembrolizumab, Lenvatinib
Clinical Study IdentifierNCT03797326
SponsorMerck Sharp & Dohme Corp.
Last Modified on19 September 2021


Yes No Not Sure

Inclusion Criteria

Has a histologically or cytologically-documented, advanced (metastatic and/or unresectable) solid tumor that is incurable and for which prior standard systemic therapy has failed in one of the following cohorts: TNBC, Ovarian Cancer, Gastric Cancer, Colorectal Cancer, GBM, BTC (intrahepatic, extrahepatic cholangiocarcinoma and gall bladder cancer; excludes Ampulla of Vater), Pancreatic Cancer
Must have progressed on or since the last treatment
Has measurable disease per RECIST 1.1 (RANO for the GBM cohort) as assessed by the local site investigator/radiology and confirmed by BICR
Has provided a PD-L1 evaluable archival tumor tissue sample or newly obtained core or excisional biopsy of a tumor lesion not previously irradiated
Male participants agree to use approved contraception during the treatment period for at least 7 days after the last dose of lenvatinib, or refrain from heterosexual intercourse during this period
Female participants are not pregnant or breastfeeding, and are not a woman of childbearing potential (WOCBP), OR are a WOCBP that agrees to use contraception during the treatment period (or 14 days prior to the initiation of study treatment for oral contraception) and for at least 120 days post pembrolizumab, or 30 days post lenvatinib, whichever occurs last
Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 within 3 days of study treatment initiation
Has adequate organ function
For Triple Negative Breast Cancer Participants
Has received one or 2 prior lines of therapy
Has Lactate Dehydrogenase (LDH) <2.0 x Upper Limit of Normal (ULN)
Has locally determined results for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 tumor analyses
For Ovarian Cancer Participants
Has primary ovarian cancer and has received 3 prior lines of therapy
For Gastric Cancer Participants
Has received 2 prior lines of therapy. Note: Gastric cancer will include participants with both gastric and gastroesophageal junction (GEJ) adenocarcinoma. Participants with squamous cell carcinoma histology are not eligible
For Colorectal Cancer Participants
Has received 2 prior lines of therapy
For GBM Participants
Has failed initial systemic therapy for newly diagnosed GBM
Have the following time periods elapsed before the projected start of scheduled study treatment: 1) at least 3 weeks from prior surgical resection, 2) at least 1 week from stereotactic biopsy, 3) at least 6 months from completion of prior radiotherapy, 4) at least 4 weeks (or 5 half-lives, whichever is shorter) from any investigational agent, 5) at least 4 weeks from cytotoxic therapy, 6) at least 6 weeks from antibodies, 7) at least 4 weeks (or 5 half-lives, whichever is shorter) from other antitumor therapies and 1 week for cancer vaccines
Be neurologically stable (e.g. without a progression of neurologic symptoms or requiring escalating doses of systemic steroid therapy within last 2 weeks) and clinically stable
Has histologically confirmed World Health Organization (WHO) Grade IV GBM
For Biliary Tract Cancer Participants
Has locally determined result for O^6-methylguanine-DNA methyltransferase (MGMT) analysis
Has received 1 prior line of therapy
Child-Pugh Score, Class A: well-compensated disease. Child-Pugh Score of 5-6
For Pancreatic Cancer Participants
Has pathologically (histologically or cytologically) confirmed pancreatic ductal adenocarcinoma that is metastatic at enrollment
Has received one or 2 prior lines of therapy
Has received prior therapy with at least 1 (platinum-containing regimen or gemcitabine-containing regimen) but no more than 2 prior systemic therapies for unresectable or metastatic pancreatic cancer

Exclusion Criteria

Has present or progressive accumulation of pleural, ascitic, or pericardial fluid requiring drainage or diuretic drugs within 2 weeks prior to enrollment (applies to all cohorts except the ovarian cancer cohort)
Has clinical significant hemoptysis or tumor bleeding within 2 weeks prior to the first dose of study treatment
Has a history of arterial thromboembolism within 12 months of start of study treatment
Has gastrointestinal malabsorption or any other condition that might affect the absorption of lenvatinib
Has a known additional malignancy that is progressing or has required active treatment within the past 3 years
Has had major surgery within 3 weeks prior to first dose of study interventions
Has radiographic evidence of encasement or invasion of a major blood vessel or of intratumoral cavitation. Participants with portal vein invasion (Vp4), inferior vena cava, or cardiac involvement based on imaging in the BTC cohort are not eligible for enrollment
Has significant cardiovascular impairment within 12 months of the first dose of study treatment, such as history of congestive heart failure greater than New York Heart Association (NYHA) Class II, unstable angina, myocardial infarction or cerebrovascular accident (CVA), or cardiac arrhythmia associated with hemodynamic instability
Has preexisting Grade 3 gastrointestinal (GI) or non-gastrointestinal fistula
Has received prior therapy with lenvatinib, an anti-PD-1, anti-PD-L1, or anti PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g. cytotoxic T-lymphocyte-associated protein 4 [CTLA-4], Tumor necrosis factor receptor superfamily, member 4 [OX 40], tumor necrosis factor receptor superfamily member 9 [CD137])
Has a serious nonhealing wound, ulcer or bone fracture
Has received prior systemic anti-cancer therapy including investigational agents within 4 weeks prior to study treatment start
If participant received major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention prior to starting study treatment
Has biologic response modifiers therapy (e.g. granulocyte colony-stimulating factor) within 4 weeks before study entry
Has received prior radiotherapy within 2 weeks of start of study treatment. Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis. A 1-week washout is permitted for palliative radiation (2 weeks of radiotherapy) to non-central nervous system (CNS) disease
Has received a live vaccine within 30 days prior to the first dose of study treatment
Has known intolerance to lenvatinib (and/or any of the excipients)
Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment
Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior the first dose of study treatment
Has known active CNS metastases and/or carcinomatous meningitis
Has tumors involving the brain stem
Has severe hypersensitivity (Grade 3) to pembrolizumab and/or any of its excipients
Has an active autoimmune disease that has required systemic treatment in past 2 years
Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis
Has an active infection requiring systemic therapy
Has a known history of human immunodeficiency virus (HIV) infection
Has a known history of hepatitis B or known active hepatitis C virus infection
Has a known history of active tuberculosis (TB; Bacillus tuberculosis)
Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the screening visit through 120 days after the last dose of study treatment
Has had an allogenic tissue/solid organ transplant (large organ transplants, stem-cell transplant requiring chronic immunosuppressant therapy necessary to prevent graft rejection)
For GBM Participants
Has carcinomatous meningitis
Has recurrent tumor greater than 6 cm in maximum diameter
Has tumor primarily localized to the brainstem or spinal cord
Has presence of multifocal tumor, diffuse leptomeningeal or extracranial disease
Has evidence of intratumoral or peritumoral hemorrhage on baseline magnetic resonance imaging (MRI) scan other than those that are grade 1 and either post-operative or stable on at least 2 consecutive MRI scans
Has received Optune TTFields within 2 weeks of study intervention
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