Neuromuscular Electrical Stimulation For The Treatment of Diabetic Peripheral Neuropathy (NMES for DPN)

  • STATUS
    Recruiting
  • End date
    Dec 31, 2023
  • participants needed
    190
  • sponsor
    Imperial College London
Updated on 23 March 2022
diabetes
burning sensation
weakness
burning
nerve conduction
numbness
nerve conduction study
peripheral neuropathy
nerve conduction studies
diabetic peripheral neuropathy
foot ulceration

Summary

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, affecting almost 50% of people with diabetes over the course of their lives. Symptoms vary from numbness to burning, aching and hypersensitivity in the lower limbs, indicative of sensory nerve loss. Motor neurons can also be affected, leading to muscle weakness and mobility issues, thus preventing patients from engaging in daily routines. Further sequelae include foot ulceration and Charcot's neuroarthropathy, which are risk factors for lower limb amputation and mortality. In the United Kingdom, the annual costs of DPN alone exceed £300 million, with further complications expected to cost an additional £1 billion. Currently, management strategies for DPN focus on prophylaxis and pain management. Neuromuscular electrical stimulation (NMES) is a novel nonpharmacological intervention for people with DPN. NMES is the application of electrical impulses which are of sufficiency intensity to improve artificial contraction of the muscle tissue and may help with DPN by improving microvascular blood flow and nerve conductivity by direct stimulation of the nerves.

Details
Condition Diabetic Peripheral Neuropathy, Diabetic Neuropathies, Diabetic Polyneuropathy, Diabetic Complication
Treatment Revitive Medic (Actegy Ltd), Revitive Medic Coach (Actegy Ltd), Sham Revitive Medic Coach (Actegy Ltd)
Clinical Study IdentifierNCT03767478
SponsorImperial College London
Last Modified on23 March 2022

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