Last updated on December 2018

Effects of High-frequency Electrical Stimulation for Preventing Loss of Muscle Mass in Patients With Sepsis


Brief description of study

Background: Electrical stimulation has been used in critical patients as an adjunct strategy of early rehabilitation. In septic or septic shock patients there are reports of only two studies in the literature, with conflicting results.

Objective: To evaluate the effects of high frequency electrical stimulation in the prevention of muscle mass loss in patients admitted to the ICU with sepsis or septic shock.

Methods: This is a randomized, controlled, double-blind clinical trial. Thirty-six patients with a diagnosis of sepsis or septic shock in the experimental group (high frequency electrical stimulation) and sham group will be randomized. They will be evaluated in relation to muscle mass, peripheral muscle strength and functional status. They will also be submitted to the collection of inflammatory, metabolic, damage and muscular trophism markers.

Expected results: High-frequency electrical stimulation is expected to be able to prevent loss of muscle mass in patients admitted to the ICU with sepsis or septic shock. In addition, it is expected to be able to preserve strength in this population without increasing the pro-inflammatory or metabolic response.

Detailed Study Description

This is a randomized, controlled, double-blind clinical trial. Thirty-six patients with a diagnosis of sepsis or septic shock in the experimental group (high frequency electrical stimulation) and sham group will be randomized. They will be evaluated in relation to muscle mass, peripheral muscle strength and functional status. They will also be submitted to the collection of inflammatory, metabolic, damage and muscular trophism markers.

Clinical Study Identifier: NCT03754257

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